Development of microparticles and microparticulated tablets containing piperine

Piper nigrum (black pepper) is used in Indian traditional medicine and its main alkaloid, Piperine (PIP), presents antioxidant, antitumor neuroprotective pharmacological properties. This substance insoluble aqueous media can irritate the gastrointestinal tract. Aiming to avoid these inconvenient characteristics enable PIP oral administration, this study suggested microencapsulation through emulsion-solvent evaporation method preparation of microparticulated tablets by direct compression. An UV-spectroscopy was validated quantify PIP. Microparticles were successfully obtained microparticles exhibited excellent flow. The scanning electron microscopy images showed that intact after vitro release a controlled from comparison tablets. profiles similar. Therefore, containing are promising multiparticulated dosage forms because tablet allows administration ones promote release, decreasing irritating potential on mucosa.